My Research Interest
My research interest is in the field of female reproductive biology, specifically placenta development and pregnancy pathology. The placenta is a transient but a vital organ that is crucial for pregnancy establishment, maternal health, and fetal development. It is mainly composed of three trophoblast subtypes: cytotrophoblasts, syncytiotrophoblasts and extravillous trophoblasts.
Current evidence indicates that abnormal placenta development is associated with pregnancy complications such as preeclampsia, miscarriage, fetal growth restriction and still birth but the underlying mechanisms remain to be clarified. Also, the prevalence of these pregnancy complications is high. However, appropriate proactive therapeutic interventions against them are limited partly due to their mysterious pathophysiology.
My aim is to contribute to clarifying the mechanism of human placenta development, assessing the toxicological effects of environmental chemicals on placenta development, unravelling the pathophysiology of placenta-associated pregnancy complications, and identifying therapeutic targets, drugs, and biomarkers for the clinical management of pregnancy complications.
Recent Publications
- Adu-Gyamfi EA, Salamah J, Cheeran EA, Lee B-K. Bisphenol S moderately decreases the expression of syncytiotrophoblast marker genes and induces apoptosis in human trophoblast lineages. Environ Pollut 2024; 343:123259.
- Adu-Gyamfi EA, Cheeran EA, Salamah J, Enabulele DB, Tahir A, Lee B-K. Long non-coding RNAs: a summary of their roles in placenta development and pathology. Biol Reprod 2024:ioad179.
- Adu-Gyamfi, E. A., Rosenfeld, C. S., & Tuteja, G. (2022). The impact of bisphenol A on the placenta. Biology of Reproduction, 106(5), 826-834.
- Kim, M., Adu-Gyamfi, E. A., Kim, J., & Lee, B. K. (2023). Super-enhancer-associated transcription factors collaboratively regulate trophoblast-active gene expression programs in human trophoblast stem cells. Nucleic Acids Research, gkad215.
- Lee, B. K., Salamah, J., Cheeran, E., & Adu-Gyamfi, E. A. (2024). Dynamic and distinct histone modifications facilitate human trophoblast lineage differentiation. Scientific Reports, 14(1), 4505.
- Yang, J., Yao, Y. L., Lv, X. Y., Geng, L. H., Wang, Y., Adu-Gyamfi, E. A., ... & Ding, Y. B. (2025). The Safety and Efficacy of inactivated COVID-19 vaccination in couples undergoing assisted reproductive technology: A prospective cohort study. Vaccine, 45, 126635.